Dr. Surangi Jayawardena

Assistant Professor, Chemistry Department Research Page

Biography

Dr. Jayawardena’s research focuses on theranostic nanostructures capable of providing both therapeutic and diagnostics in-vivo and in-vitro environments for infectious diseases. Design of theses theranostic systems involve synthesis of nanoparticle cores with diagnostic aids such as fluorescence, magnetic resonance, along with surface modification chemistry to modify particle surface to carry biorecognition molecules, small molecule drugs and biocompatible polymers for targeted therapy. Her laboratory utilizes synthetic analytical and material characterization techniques to design theranostic systems, these include small molecule synthesis for bioconjugation, synthesis of various inorganic and organic nanomaterial and application in ex-vivo, in-vitro and in-vivo settings.

Dr. Surangi Jayawardena's Curriculum Vitae


Education

  • Postdoctoral Research Associate, Department of Chemical Engineering, Massachusetts Institute of Technology, 2017
  • Ph.D., Organic Chemistry, University of Massachusetts Lowell, 2014
  • B.S., Chemistry, University of Colombo, Sri Lanka, 2008

Publications

  • Chen, X.; Wu, B.; Jayawardana, K. W.; Hao, N.; Jayawardena, H. S. N.; Langer R.; Jaklenec, A.; Yan, M. Magnetic multivalent trehalose glycopolymer nanoparticles for the detection of mycobacteria, Adv. Healthc. Mater. 2016.
  • Zhang, Y.; Jayawardena, H. S. N.; Yan, M.; Ramstrom, O. Enzyme classification using complex dynamic hemithioacetal systems. Chem. Commun. 2016.
  • Sundhoro, M.; Wang, H.; Boiko, S. T.; Chen, X.; Jayawardena, H. S. N.; Park, J.; Yan, M. Fabrication of carbohydrate microarrays on a poly (2-hydroxyethyl methacrylate)-based photoactive substrate. Organic & biomolecular chemistry 2016, 14, 1124-1130.
  • Park, J.; Jayawardena, H. S. N.; Chen, X.; Jayawadana, K.; Sundhoro, M.; Ada, E.; Yan, M. A General Method for the Fabrication of Graphene-Nanoparticle Hybrid Material. (2015) Chem. Commun. 2015, 51, 2882–2885
  • Jayawardana, K. W.; Jayawardena, H. S. N.; Wijesundera, S. A.; De Zoysa, T.; Sundhoro, M.; Yan, M. Selective targeting of Mycobacterium smegmatis with trehalose-functionalized nanoparticles. Chem. Commun. 2015, 51, 12028-12031.
  • Zhou, J.; Butchosa, N.; Jayawardena, H. S. N.; Park, J.; Zhou, Q.; Yan, M.; Ramström, O. Synthesis of Multifunctional Cellulose Nanocrystals for Lectin Recognition and Bacterial Imaging. Biomacromolecules 2015, 16, 1426-1432.
  • Park, J.; Jayawardena, H. S. N.; Chen, X.; Jayawardana, K. W.; Sundhoro, M.; Ada, E.; Yan, M. A general method for the fabrication of graphene-nanoparticle hybrid material. Chem. Commun. 2015, 51, 2882-2885.
  • Zhou, J.; Butchosa, N.; Jayawardena, H. S. N.; Zhou, Q.; Yan, M.; Ramström, O. Glycan-Functionalized Fluorescent Chitin Nanocrystals for Biorecognition Applications. Bioconjugate Chem. 2014, 25, 640-643.
  • Chaudhary, S.; Kamra, T.; Uddin, K. M. A.; Snezhkova, O.; Jayawardena, H. S. N.; Yan, M.; Montelius, L.; Schnadt, J.; Ye, L. Controlled short-linkage assembly of functional nano-objects. Appl. Surf. Sci. 2014, 300, 22-28
  • Jayawardena, H. S. N.; Wang, X.; Yan, M. Classification of Lectins by Pattern Recognition Using Glyconanoparticles. Anal. Chem. 2013, 85, 10277-10281.
  • Jayawardena, H. S. N.; Jayawardana, K. W.; Chen, X.; Yan, M.: Maltoheptaose promotes nanoparticle internalization by Escherichia coli. Chem. Commun. 2013, 49, 3034-3036.
  • Xu, C.; Uddin, K. M. A.; Shen, X.; Jayawardena, H. S. N.; Yan, M.; Ye, L. Photoconjugation of Molecularly Imprinted Polymer with Magnetic Nanoparticles. ACS Appl. Mater. Interfaces 2013, 5, 5208-5213.