Dr. John Shriver

Emeritus Professor, Biological Sciences Department Emeritus Professor, Chemistry Department

Biography

My research focus prior to retirement in May 2016 was on studies of DNA binding proteins from extreme thermophiles as model systems for elucidating the binding energetics of key proteins in human biochemistry. Our work was funded by the National Institutes of Health for nearly 30 years.

My research has now moved from Fourier analysis of nuclear magnetic resonance signals to analysis of the sound of the acoustic piano with the goal of achieving the perfect tune. This includes investigations of the effect of string inharmonicities on piano tuning, as well as voicing of the hammers and regulation of the action.


Education

  • Ph.D., Chemistry, Case Western Reserve University, 1977
  • B.S., Biology, West Virginia University, 1971

Classes Taught

  • CH 345 Experimental Physical Chemistry I
  • CH 347 Biophysical Chemistry I (cross listed as BYS 347)
  • CH 361 General Biochemistry
  • CH 561 Graduate Biochemistry (cross listed as BYS 547)

Publications

  • "Unprotonated Chromophore-Protein Bond in Visual Pigments form 13C NMR Spectra", John W. Shriver, Gheorghe Mateescu, Roger Fager, Dennis Torchia, and E. W. Abrahamson. Nature 270, 271 (1977).
  • "NMR Product Operator Calculations in Mathematica", Shriver, J. Journal of Magnetic Resonance 94, 612-616 (1991).
  • "Defining the Precision with which a Protein Structure is Determined by NMR. Application to Motilin", Shriver, J. and S. Edmondson, Biochemistry 32, 1610-17 (1993).
  • "Solution Structure of the DNA-Binding Protein Sac7d from the Hyperthermophile Sulfolobus acidocaldarius" Edmondson, S. , Qiu, L., and Shriver, J. Biochemistry 34, 13289-13304 (1995).
  • "The hyperthermophile chromosomal protein Sac7d sharply kinks DNA" Robinson, H., Gao, Y.-G, McCrary, B.S., Edmondson, S.P., Shriver, J.W., and Wang, A.H.-J. Nature 392, 202-205 (1998).
  • "Carboxyl pKa Values, Hydrogen Bonding, and the pH Dependence of Folding Sac7d and Sso7d" Clark, A.R., Smith, K., Muhandiram, R., Edmondson, S.P. and Shriver, J.W. J. Mol. Biol. 28, 992-1008 (2007).