Gordon Macgregor

Dr. Gordon MacGregor

Assistant Professor, Biological Sciences Department

Biography

The goal of our laboratory is to understand the body's regulation of water and electrolyte balance. Disorders of water balance such as diarrhea (dehydration), and hyponatremia (water toxicity) can be rapidly fatal, and we seek novel, cheap and affordable pharmaceutical cures. The techniques we use are Ussing chambers, patch clamp and modern molecular and biophysical techniques to work on mouse models of disease.

Education

  • Ph.D., University of Dundee, 1995
  • M.S., Child Health, University of Dundee, 1992
  • B.S., Biochemistry, University of St. Andrews, 1991

Classes Taught

Publications

  • Vucic E, Alfadda T, MacGregor GG, Dong K, Wang T, Geibel JP. Kir1.1 (ROMK) and Kv7.1 (KCNQ1/KvLQT1) are essential for normal gastric acid secretion: importance of functional Kir1.1. Pflugers Arch. 2015 Jul; 467(7):1457-68.
  • "An NH2-Terminal Multi-basic RKR Motif is required for the ATP-dependent regulation of hIK1." Channels. 1(2): e1-e12. Heather M. Jones, Mark A. Bailey, Catherine J. Baty, Gordon G. MacGregor, Colin A. Syme, Kirk L. Hamilton, Daniel C. Devor (2007).
  • "Mechanism of urinary potassium excretion in the ROMK-deficient mouse model of type II Bartter's syndrome." Kidney International. 70: 51-59. Matthew A. Bailey, Alessandra Cantone, Q. Yan, Gordon G. MacGregor, Qiang Leng, J.B.O. Amorim Tong Wang, Steven C. Hebert, Gerhard Giebisch and Gerhard Malnic (2006).
  • " Subunit-subunit interactions are critical for proton sensitivity of ROMK – evidence in support of an intermolecular gating mechanism." Proc Natl Acad Sci USA. 103: 1982-1987. Qiang Leng, Gordon G. MacGregor, Ke Dong, Gerhard Giebisch and Steven C. Hebert (2006).
  • "WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalemia, regulates the K+ channel ROMK1 (Kir1.1)." J. Physiol. 571: 275-286. Qiang Leng, Kristopher T. Kahle, Jesse Rinehart, Gordon G. MacGregor, Frederick H. Wilson, Cecilia M. Canessa, Richard P. Lifton and Steven C. Hebert (2006).
  • "Related Articles, Phosphorylation-regulated endoplasmic reticulum retention signal in the renal outer-medullary K+ channel (ROMK)." Proc Natl Acad Sci USA. 102: 9954-9. O'Connell AD, Leng Q, Dong K, MacGregor GG, Giebisch G, Hebert SC (2005).
  • "Novel Nucleotide Binding-Sites in ATP-Sensitive Potassium channels Formed at Gating Interfaces." EMBO J. 24: 1318-1329. Dong, K., L-Q. Tang, G. G. MacGregor, Q. Leng and S. C. Hebert (2005).
  • "Paracellular Cl- permeability is regulated by WNK4 kinase: insight into normal physiology and hypertension." Proc Natl Acad Sci USA. 101(41):14877-82. Kahle KT, MacGregor GG, Wilson FH, Van Hoek AN, Brown D, Ardito T, Kashgarian M, Giebisch G, Hebert SC, Boulpaep EL, Lifton RP (2004).
  • "WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion." Nature Genetics. 35: 372-376. Kahle, K. T., F. H. Wilson, Q. Leng, M. D. Lalioti, A. D. Connell, K. Dong, A. K. Rapson, G. G. MacGregor, G. Giebisch, S. C. Hebert, R. P. Lifton (2003).
  • "Localization of the ATP/PIP2-binding site to a 39 amino acid region of the carboxy-terminus of the ATP-regulated K+ channel Kir1.1." J Biol Chem. 277(51):49366-73. Dong, K., L-Q. Tang, G. G. MacGregor, S. C. Hebert (2002).
  • "Nucleotides and phospholipids compete for binding to the C terminus of KATP channels." Proc. Natl. Acad. Sci. USA. 99: 2726-2731. MacGregor G. G., K. Dong, C. G. Vanoye, L. Tang, G. Giebisch, S. C. Hebert (2002).
  • "The carboxyl termini of K(ATP) channels bind nucleotides." J. Biol. Chem. 277: 23260-23270. Vanoye, C. G., G. G. MacGregor, K. Dong, L-Q. Tang, A. S. Buschmann, A. E. Hall, M. Lu, G. Giebisch and S. C. Hebert (2002).
  • "Fatty acid modulation and sequence identity of fetal guinea pig alveolar type II cell amiloride-sensitive Na+ channel." Biochem. Biophys. Res. Commun. 288: 727-735. Baines, D. L., G. G. MacGregor, P. J. Kemp (2001).
  • "An amino acid triplet in the NH2 terminus of rat ROMK1 determines interaction with SUR2B." J Biol. Chem. 276: 44347-44353. Dong, K., J. Xu, C. G. Vanoye, R. Welch, G. G. MacGregor, G. Giebisch, S. C. Hebert (2001).
  • "Inactivating properties of recombinant ROMK2 channels expressed in mammalian cells." Biochem Biophys Res Commun. 286: 376-380. Riochet, D. F. L., R, Mohammad-Panah, S. C. Hebert, G. G. MacGregor, I. Baró, G. Guihard, D. Escande (2001).
  • "PKA site mutations of ROMK2 channels shift the pH-dependence to more alkaline values." Am. J. Physiol. 279: F919-F926. Leipziger, J, G. G. MacGregor, G. J Cooper, J. Xu, S. C. Hebert and G. Giebisch (2000).
  • "Extracellular ATP inhibits the small-conductance K channel on the apical membrane of the cortical collecting duct from mouse kidney." J. Gen. Physiol. 116: 299-310. M. Lu, G. G. MacGregor, W. Wang and G. Giebisch (2000).
  • "Partially active channels produced by PKA site mutation of the cloned renal K+ channel ROMK2 (Kir1.2)." Am. J. Physiol. 275: F415-F422. G. G. MacGregor, J. Z. Xu, C. M. McNicholas, G. Giebisch and S. C. Hebert (1998).
  • "pH-dependent modulation of the cloned renal K+ channel, ROMK." Am. J. Physiol. 275: F972-F981. C. M. McNicholas, G. G. MacGregor, L. D. Islas, Y. Yang, S. C. Hebert and G. Giebisch (1998).
  • "Amiloride-sensitive Na+ channels in fetal type II pneumocytes are regulated by G proteins." Am. J. Physiol. 267: L1-L8. G. G. MacGregor, R. E. Olver, P. J. Kemp (1994).