Dr. Krishnan Chittur Professor Emeritus, Chemical and Materials Engineering Department Biography Dr. Chittur has more than 25 years experience working on problems that arise from medicine or biology. Dr. Chittur has used Fourier transform infrared spectroscopy to understand the relationship between biomaterial surface properties and protein adsorption, leading in turn to solving problems in biocompatibility. Dr. Chittur helped write a proposal leading to the UAH campus Ph.D. program in Biotechnology Science and Engineering. Dr. Chittur directed that Ph.D. program for four years. Dr. Chittur's research interests today are in understanding gene expression and techniques to study them. Dr. Chittur is interested in expanding (and using) open source software for engineering education - and has been a mentor to several students with the Google Summer of Code and the Project ASCEND Dr. Krishnan Chittur's Curriculum Vitae Education Ph.D., Chemical Engineering, Rice University, Houston, Texas, 1984 B.Tech., Chemical Engineering, Indian Institute of Technology, Bombay, India, 1979 Classes Taught ChE 197 - INTRO CHEMICAL ENGR PROCESSES ChE 244 - INTRO TO CHEM ENGRG SYSTEMS ChE 294 - NATURE & PROPERTIES OF MATLS ChE 344 - CHEM ENGR THERMODYNAMICS ChE 440 - UNIT OPERATIONS II ChE 443 - MASS TRANSFER OPERATIONS ChE 448 - CHEMICAL ENGINEERING DESIGN ChE 460/560 - INTRO TO BIOPROCESS ENGRG ChE 461/561 - BIOSEPARATIONS ChE 649 - TRANSPORT PHENOMENA II ChE 747 - ADV TOP/BIOENGINEERING ChE 659 - SELECTED TOPICS/CHE BSE 620 - INT BIOINFORMATICS:FUND/METHOD BSE 621 - INT BIOINFORMATICS:COMP LAB AP Publications 1. Sanja Glisic, David P. Cavanaugh, Krishnan K. Chittur, Milan Sencanski, Vladimir Perovic and Tijana Bojic: Common molecular mechanism of the hepatic lesion and the cardiac parasympathetic regulation in chronic hepatitis C infection: a critical role for the muscarinic receptor type (BMC Bioinformatics, Accepted, January 2016) 2. David P. Cavanaugh, Krishnan K. Chittur: A hydrophobic proclivity index for protein alignments, Faculty of 1000 (Research) (In Press, September 2015) 3. Jonas Boateng, Robert Zahorchak, Joel Peek, Krishnan Chittur Novel stem-loop probe DNA arrays: Detection of specific acetotrophic 16S ribosomal RNA signatures, Analytical Bio- chemistry, Vol 435, pp 60–67 2013. 10.1016/j.ab.2012.12.006 4. Jonas Boateng, Joel Peek, Robert Zahorchak, Krishnan Chittur Dendron modified surfaces provide an ideal environment for stem loop DNA probes, Analytical Biochemistry, Vol 430, pp 39–44, 2012. http://dx.doi.org/10.1016/j.ab.2012.07.021 5. Xhuang, Fei, Chittur, Krishnan, Mount, Dwight, Smith, Stephen, Hayes, Douglas Simple and Inexpensive Preparation of Long-Lasting Insecticidal Nets Via Co-Adsorption of Pyrethroid and Oligomer Textile Research Journal, Vol 78, Number 7, pp 595603 (July, 2008) 6. M. Elena Diaz, B. Johnson, Krishnan K. Chittur, Ramon L. Cerro (2005) Infrared Spectroscopy analysis of the structure of multilayer Langmuir-Blodgett Films: Effect of deposition velocity and pH: Langmuir, Vol 21(2), pp 610-6 7. Susan M. McCormick, S.R. Frye, Suzanne G. Eskin, Christina L. Teng, Chiung-Mei Lu, Christopher G. Russell, Krishnan K. Chittur, Larry V. McIntire (2003) Microarray analysis of shear stressed endothelial cells Biorheology, Vol 40, pp 5—11. 8. Susan M. McCormick, Suzanne G. Eskin, Larry V. McIntire, Christina L. Teng, Chiung-Mei Lu, Christopher G. Russell, Krishnan K. Chittur DNA Microarray Reveals Changes in Gene Expression of Shear Stressed Human Umbilical Vein Endothelial Cells Proceedings of the National Academy of Sciences, USA, Vol 98, Number 16, pp 8955—8960, July 31, 2001 9. Jing Xie, Clyde Riley and Krishnan Chittur(2001) Effect of albumin on brushite trans- formation to hydroxyapatite Journal of Biomedical Materials Research, Vol 57, No. 3, pp -65 10. Mukesh Kumar, Jing Xie, Krishnan K. Chittur, Clyde Riley, (1999) Transformation of Modified Brushite to Hydroxyapatite in Simulated Body Fluid: Effects of Potassium Substitution. Biomaterials, 20, 1389–1399. 11. Haitong Zeng, Krishnan K. Chittur, William R. Lacefield (1999), Dissolution/Reprecipitation of Calcium Phosphate Thin Films Produced by Ion Beam Sputter Deposition Technique, Biomaterials, 20, 443–451. 12. Haitong Zeng, Krishnan K. Chittur, William R. Lacefield (1999), Analysis of bovine serum albumin adsorption on calcium phosphate and titanium surfaces, Biomaterials, 20, 377— 384 13. Jeannie D. Haman, Krishnan K. Chittur, Daryl E. Crawmer and Linda C. Lucas (1999) Analytical and Mechanical Testing of High Velocity Oxy-Fuel Thermal Sprayed and Plasma Sprayed Calcium Phosphate Coatings, J. Biomed. Mater. Res (Appl. Biomater.), Vol 48, pp 856–860. 14. Krishnan K. Chittur FTIR and Protein Structure at Interfaces, Bulletin of the Biomedical Engineering Society, Volume 23, Number 3, 1999 15. Chittur, K.K. (1998) Surface Techniques to Examine the Biomaterial-Host Interface: An Introduction to the Papers, Biomaterials, 19, 301–305. 16. Chittur,K.K.(1998)FTIR/ATRforProteinAdsorptiontoBiomaterialSurfaces,Biomaterials, 19, 357–369. 17. Chittur, K.K. (1998) Proteins on Surfaces: Methodologies for Surface Preparation and Engineering Protein Function, In ”Biopolymers at Interfaces“, Elsevier Surfactant Science Series, Ed. Martin Malmsten, Chapter 6, pp 143–179. 18. Noh,K.K.Chittur,S.L.Goodman,J.A.Hubbell(1997)Surface Modification of Poly(tetrafluoroethylene) with benzophenone and Sodium Hydride by Ultraviolet Radiation. J. Poly. Sci. A: Polym. Chem. Ed. 35, 1499-1514. 19. Nadarajah,A.,LuC.F. and ChitturK.K.(1995)Modeling the dynamics of protein absorption to surfaces, In: T. Horbett and J. Brash (Editors) ”Proteins at Interfaces San Diego 1994“, ACS Symposium Series, Chapter 13, pages 181–194. 20. Lu, C.F., Nadarajah, A.and Chittur, K.K. (1994) A Comprehensive Model for Protein Ad- sorption to Surfaces. J.Coll.Int.Sci., 168, 152-161. 21. J.L.Ong,K.K.Chittur and L.C.Lucas(1994)Dissolution/reprecipitation and protein absorption studies of calcium phosphate coatings by FT-IR/ATR techniques. J. Biomed. Mater. Res., 28, 1337-1346. 22. Cheng, S.S., Chittur, K.K., Sukenik, C.N., Culp, L.A. and Lewandowska, K. (1994) The conformation of fibronectin on self-assembled monolayers with different surface composition: An FT-IR/ATR study. J.Coll.Int.Sci., 162, 135. 23. Lenk, T.J., Ratner, B.D., Horbett, T.A. and Chittur, K.K. (1991) Infrared spectroscopic studies of time-dependent changes in fibrinogen adsorbed to polyurethanes. Langmuir, 7, 1755. 24. Lenk, T.J., Ratner, B.D., Chittur, K.K., Gendreau, R.M. (1989) IR spectral changes of bovine serum albumin upon surface adsorption. J. Biomed. Mater. Res., 23, 549. 25. Lipkus, A.H., Chittur, K.K., Robinson J.B., Pierce, G. (1990) Evaluation of Infrared Spectroscopy as a Bacterial Identification Method. J. Ind. Microbiol., 6, 71. 26. Lipkus, A.H., Lenk, T.J., Chittur, K.K., Gendreau, R.M. (1988) Cluster Analysis of Protein FTIR Spectra. Biopolymers, 27, 1831. 27. Nyden, M. and Chittur, K.K. (1988) Component Spectrum Reconstruction from Partially Characterized Mixtures, Appl. Spectrosc., 43, 123-128. 28. Nyden, M., Forney, G. and Chittur, K.K. (1988) Spectroscopic Quantitative analysis of Strongly Interacting Systems: Human Plasma Protein Mixtures. Appl. Spectrosc., 42, 588594. 29. Chittur, K.K., McIntire, L.V., Rich, R.R. (1988) Shear Stress effects on Human T Cell Function. Biotech. Prog., 4, 8996. 30. Nocentini, M., Gendreau, R.M., Chittur, K.K. (1988) Conformational changes of protein adsorbed on polyurethane studied by FT-IR/ATR spectroscopy. Mikrochim. Acta (Wien) I, 343. 31. Gendreau, R.M., Chittur, K.K., Dluhy, R.A. and Hutson, T.B. (1987) Biological FTIR Spectroscopy: An Overview. International Laboratory, Nov/Dec Issue, 15-21. 32. Tingey, K.G., Andrade J.D., Zdrahala, R.J., Chittur, K.K., Gendreau, R.M. (1988) Surface analysis of polyether and polysiloxane soft segment polyurethanes. In ”Surface Characterization of Biomaterials”. Ed. B.D. Ratner, Elsevier, Amsterdam, 255. 33. Fink, D.J., Hutson, T.B., Chittur, K.K., Leininger, R.I. and Gendreau, R. M. (1987) Quantitative surface studies of protein adsorption by infrared spectroscopy. II. Quantitation of adsorbed and bulk proteins. Anal. Biochem., 165, 147. 34. Chittur, K.K., Fink, D.J., Leininger, R.I., Hutson, T.B. (1986). FTIR/ATR studies of protein adsorption in flowing systems. Approaches for bulk correction and compositional analysis in mixtures. J. Coll. Int. Sci, 111, 419. 35. Chittur, K.K., Fink, D.J., Hutson, T.B., Gendreau, R.M., Jakobsen, R.J. and Leininger, R.I., FTIR/ATR Studies of protein adsorption in flowing systems. ACS Symposium Series ”Proteins at Interfaces“ based on symposium at Anaheim, Sept. 712, 1986, 343, 362377. 36. Chittur, K.K. and Fink, D.J. (1986). Monitoring Biological Processes by Fourier Transform Infrared Spectroscopy. Enzy. and Microb. Tech., 9, 568572.