Dr. Joseph D. Ng

Professor, Biological Sciences Coordinator,
BSE Program


301 Sparkman Drive
Shelby Center
Room 369J
Huntsville, AL 35899
Campus Map



Dr. Joseph (Joe) Ng received his doctorate degree in Biochemistry from the University of California, Riverside and did his postdoctoral work studying macromolecular crystal growth and X-ray crystallography at The National Center for Scientific Research (CNRS) in France.  Dr. Ng’s research combines the techniques of molecular biology, protein chemistry and X-ray crystallography to decipher the three-dimensional structure of proteins associated with essential biological functions and genomics.  Most recently, his laboratory has been studying the gene products and their functions associated with inflammation, Post-Traumatic Stress Disorder (PTSD) and SARS-CoV-2 identification.  Dr. Ng is also a co-founder and President of iXpressGenes Inc at the HudsonAlpha Institute for Biotechnology.   He has been instrumental in advancing the Biotechnology community in Huntsville AL in his involvement and collaboration with the UAH business school, private companies and government laboratories.

Curriculum Vitae


  • Ph.D., Biochemistry, University of California, Riverside, 1992
  • B.S., Biochemistry, University of California, Los Angeles, 1985


  • Structural Biology and Genomics
  • Macromolecular Crystallization and Crystallography
  • Protein Engineering

Recent Publications

  • Havlickova, P., Brinsa, V., Brynda, J., Pachl, P., Prudnikova, T., Mesters, J.R., Kascakova, B., Kuty, M., Pusey, M.L., Ng, J.D., Rezacova, P. and Smatanova, I.K.(2019). A novel structurally characterized haloacid dehalogenase superfamily phosphatase from Thermococcus thioreducens with diverse substrate specificity. Acta Cryst. D75, 743-752

  • Ng, J.D., Baird, J.K., Coates, L., Garcia-Ruiz, J.M., Hodge, T.A. and Huan, S. (2015). Large volume protein crystal growth for Neutron Macromolecular Crystallography. Acta Crystallogr Sect F Struct Biol Cryst Commun. 71:358-370.

  • Pusey, M., Barcena, J., Morris, M., Singhal, A., Yuan, Q. and Ng, J.D. (2015). Trace fluorescent labeling for protein crystallization. Acta Crystallogr Sect F Struct Biol Cryst Commun. 71:806-814.

  • Coates, L., Tomanicek, S., Shrader, T., Weiss, K., Ng, J.D., Juttner, P. and Ostermann, A. (2014). Cryogenic neutron protein crystallography: routine methods and potential benefits. Journal of Applied Crystallography.47:1431-1434.

  • Ng, J.D., Dowell, J.J., Kar, A.K., Hansen, K., Thundat, T. and George, M.A. (2013). Measurement of temperature induced unfolding of DNA hairpins by microcantilever sensors. Open Journal of Applied Biosensor. 2:78-82.

  • Tomanicek, S.J.,Standaert, R.F., Weiss, K.L., Ostermann, A., Schrader, T.E., Ng, J.D. Coates L. (2013). Neutron and X-ray crystal structures of a perdeuterated enzyme inhibitor complex reveal the catalytic proton network of the Toho-1 ?-lactamase for the acylation reaction. J. Biol. Chem. 288(7):4715-4722.

  • Hughes, R.C., Coates, L., Blakeley, M.P., Tomanicek, S.J., Langan, P., Kovalesvsky, A., García-Ruiz, J.M. and Ng, J.D.(2012). Inorganic pyrophophatase crystals from Thermococcus thioreducens for X-ray and neutron diffraction. Acta Crystallogr Sect F Struct Biol Cryst Commun 68:1482-1487.

  • Chu, X.Q., Gajapathy, M., Weis, K., Mamontov, E., Ng, J.D. and Coates, L. (2012). Dynamic Behavior of Oligomeric Inorganic Pyrophosphatase Explored by Quasielastic Neutron Scattering. The Journal of Physical Chemistry 116:9917-9921.

  • Tomanicek, S.J., Hughes, R.C., Ng, J.D. and Coates, L. (2010). Structure of the endonuclease IV homologue from Thermotoga maritima in the presence of active-site divalent metal ions. Acta Crystallogr Sect F Struct Biol Cryst Commun 66:1003-1012.

  • Kantardjieff, K.A., Lind, C. Ng, J.D. and Santarsiero, B.(2010). Efforts to enhance coverage of crystallography in United States secondary education. J. Applied Crystallography 43, 1181–1188.