Dr. Robert McFeeters

Associate Professor - Chemistry


301 Sparkman Drive
Materials Science Building
Room 215
Huntsville, AL 35899
Campus Map



Research in our group is centered on antimicrobial development and understanding the macromolecular interactions underlying inhibition. A major project centers on essential peptidyl-tRNA hydrolase enzymes, in particular bacterial Pth1, and the ability to inhibit peptidyl-tRNA cleavage as a novel antibiotic approach. Another major project involves carbohydrate binding lectins, their interaction with pathogens, and their development as antimicrobials. Other projects involve discovery of novel antifungals and development of Site Specific Aromatic Labeling (SSAL). Overall, our interest is in understanding pathogenic phenomena at the molecular level, through the seamless integration of chemistry, biology and microbiology.

Curriculum Vitae


  • Ph.D., Molecular Medicine, Cornell University, 2002
  • B.S., Engineering Physics, University of Colorado, Boulder, 1995


  • Biochemistry
  • Receptor-Ligand Binding
  • Macromolecular Structure/Function/Dynamics
  • Biophysics
  • Antiviral Entry Inhibition & Transcriptional Regulation of the Bacterial Nucleoid

Recent Publications

  • G. L. Burks, H. McFeeters, R. L. McFeeters, Expression, Purification, and Buffer Solubility Optimization of the Putative Human Peptidyl-tRNA hydrolase PTRHD1, Protein Expression and Purification, 126:49-54, 2016.

  • P. P. Ferguson, W. Blake Holloway, W. N. Setzer, R. L. McFeeters, Small Molecule Docking Supports Broad and Narrow Spectrum Potential for the Inhibition of the Novel Antibiotic Target Bacterial Pth1, Antibiotics, 5(2):16, 2016.

  • H. McFeeters, V. G. Vandavasi, K. Weiss, L. Coates, R. L. McFeeters, Neutron Diffraction Analysis of Pseudomonas aeruginosa Peptidyl-tRNA Hydrolase 1, Acta Crystallographica Section F, 72(3):220-223, 2016.

  • W. B. Holloway, H. McFeeters, A. M. Powell, G. S. Nidadavolu, R. L. McFeeters, A Highly Adaptable Method for Quantification of Peptidyl-tRNA Hydrolase Activity, Journal of Analytical and Bioanalytical Techniques, 6(3), 2015.

  • H. McFeeters, R. L. McFeeters, Current Methods for Analysis of Enzymatic Peptidyl-tRNA Hydrolysis, Journal of Analytical and Bioanalytical Techniques, 5(5), 2014.

  • V. Surapuram, W. N. Setzer, R. L. McFeeters, H. McFeeters, Antifungal Activity of Plant Extracts against Aspergillus niger and Rhizopus stolonifer, Natural Product Communications, 9(11):1603-1605, 2014.

  • V. Vandavasi, K. Taylor-Creel, R. L. McFeeters, L. Coates and H. McFeeters, Recombinant Production, Crystallization, and X-ray Crystallographic Structure Determination of Peptidyl- tRNA Hydrolase from S. typhimurium, Acta Crystallographica Section F, 70(7):872-877, 2014.

  • K. Taylor-Creel, M. C. Hames, W. B. Holloway, H. McFeeters, R. L. McFeeters, Expression, Purification, and Solubility Optimization of Peptidyl-tRNA Hydrolase 1 from Bacillus cereus, Protein Expression and Purification, 95:259-264, 2014.

  • J. K. Baird, R. L. McFeeters, K. G. Caraballo, Specific Rate of Protein Crystallization Determined by the Guggenheim Method, International Journal of Thermophysics, 35(5):830-840 2014.

  • M. C. Hames, H. McFeeters, W. B. Holloway, C. B. Stanley, V. S. Urban, R. L. McFeeters, Small Molecule Binding, Docking, and Characterization of the Interaction between Pth1 and Peptidyl-tRNA, International Journal of Molecular Sciences, 14:22741-22752, 2013.