Next Generation Antibiotics

Contact: Dr. Robert McFeeters

With the rise of drug resistance and overuse of antibiotics, the need for new antibiotics and new antibiotic targets is urgent and growing. Bacterial peptidyl-tRNA hydrolase is a promising new antibiotic target being developed in Dr. McFeeters research group. Structure/function and activity studies of this essential bacterial enzyme have led to development of higher throughput screening and novel small molecule inhibitor discovery. Continued inhibitor development, including sophisticated computational approaches, are underway.

New Avenues to Antifungals

Contact: Dr. Robert McFeeters

Antifungal drugs are dated and have significant unwanted side effects. Having discovered antifungal activity for high mannose binding lectins, Dr. McFeeters’ research group continues to pioneer development of this novel antifungal avenue. Protein engineering fueled by high resolution structure information and high mannose binding studies continue to improve efficacy. Understanding the mechanism of action and identification of the fungal target promise to further open this new avenue to inhibiting pathogenic fungi.