THE UNIVERSITY OF ALABAMA IN HUNTSVILLE MATHEMATICAL SCIENCES COLLOQUIUM is proud to present Dr. Fathallah Hassan from the Department of Mathematics at The University of Alabama in Birmingham giving their talk "Advancements From Multi-scale Modeling and Computational Trials For Gliomas".

Gliomas are associated with poor outcome and significant neurological morbidity. Key biological features of these malignant brain tumors include mitosis, brain invasion, and angiogenesis (new blood vessel formation). Mathematical modeling has made important contributions to the biology and clinical care of gliomas. The equations model the growth of grades 2-4 gliomas at the scales of pathology and magnetic resonance imaging; simulations yield computational trials (in silico clinical trials) that accurately predict the survival times of GBM patients. The results identify the rates of angiogenesis, migration, and replication as fundamental properties that predict survival times, response to treatment, and advancement to higher grades. The findings also uncover novel clinical behaviors, like evolution to higher grade, inability to transform, and new recurrence patterns of GBM treated by anti-angiogenic therapy. These results support the recent announcement by the Food and Drug Administration to use modeling and simulations in predicting effectiveness and clinical outcomes.

Refreshments will be served at 2:30 p.m. in SC 201 suite landing.