View Biotechnology Graduate Courses Chemistry Graduate Courses (CH) Lower Level 521 Chemical Instrumentation (4 hrs)Use of basic instrumentation in electrochemical, chromatographic, and spectrophotometric analysis. Prerequisite: Undergraduate physical chemistry laboratory. Lab Fee: $60. 525 Environmental Chemistry (3 hrs)Principles of quantitative analyses related to minor components of a sample. Applications selected from principal analyses necessary to maintain environmental quality of air, water, and soil. Selection of conditions for collecting reliable samples, concentration of components with techniques for increasing concentration of selected component, relationships between physical and chemical changes in sample and signal output of predominant transducers, and translation of chemical analysis into meaningful specifications. Lecture only. Prerequisites: Analytical chemistry or chemical instrumentation. (Same as ES 525.) 531 Theoretical Organic Chemistry (4 hrs)Molecular orbital theory and bonding, molecular structure, frontier molecular orbitals, pericyclic reactions, and reactive intermediates. Extensive computational laboratory work included. Prerequisites: Undergraduate organic chemistry and physical chemistry Lab Fee: $50. 540 Polymer Synthesis and Characterization (3 hrs)Synthesis of commercially relevant and novel polymers. Polymer characterization and discussion of the structural dependence of polymer properties. Prerequisites: Undergraduate organic chemistry. Students who have successfully completed CH 540 cannot also receive credit for MTS 649. 549 Spectroscopy and Molecular Structure (3 hrs)Intermediate level treatment of principles of spectroscopy and their application to determination of molecular structure. Prerequisite: Undergraduate physical chemistry. 553 Introductory Quantum Mechanics I (3 hrs)Waves and particles; Bohr's model of the atom; de Broglie waves, wave-packets and the uncertainty principle; postulates of quantum mechanics; Schroedinger's equation; simple systems in one, two and three dimensions; the hydrogen atom. Prerequisites: Basic physics, physical chemistry, linear algebra and differential equations. (Same as PH 551, OSE 555, MTS 651.) Fall. 554 Introductory Quantum Mechanics II (3 hrs)Angular momentum and spin; atomic structure and spectrum; time-independent pertubation theory, variational methods; time-dependent pertubation theory and interactions of light with matter; scattering theory; electronic structure of solids; relativistic quantum mechanics. Prerequisite: CH 553 or PH 551. (Same as PH 552, MTS 652.) Spring. 560 X-Ray Structure Dtermination (4 hrs)Examines both theoretical eand practical aspects of molecular structure determination by x-ray diffraction methods. Diffraction of x-rays, symmetry operations and space groups, methods of data collection, theory of structure factors and Fourier synthesis, least squares methods of structure refinement. Extensive laboratory and computer work. Prerequisites: Senior standing in chemistry or physics and approval of the instructor. Lab Fee: $60. 561 Biochemistry I (3 hrs)Structural chemistry and function of biomolecules, mechanisms of biochemical reactions, enzyme kinetics, and energy transfer. Prerequisite: Undergraduate organic chemistry or biochemistry. (Same as BYS 547.) 562 Biochemistry II (3 hrs)Metabolism, biosynthesis of macromolecular precursors, storage, transmission, and expression of genetic information, and molecular physiology. Prerequisite: CH 561 or BYS 547. (Same as BYS 548.) 565 Molecular Biochemistry Laboratory (2 hrs)Practical experience in isolation and characterization of biomolecules. Prerequisite: CH 562. Lab Fee: $60. Upper Level 600 Advanced Inorganic Chemistry (3 hrs)Survey with emphasis on structure and reactivity of inorganic compounds. Prerequisite: Undergraduate inorganic chemistry. 601 Structural Methods in Inorganic Chemistry (3 hrs)Physical methods applied to determination of structure of inorganic compounds. Prerequisite: CH 600. 602 Chemistry of Coordination Compounds (3 hrs)Modern bonding theory and stereochemistry of coordination compounds. Prerequisite: CH 600. 603 Chemistry of Nonmetal Compounds (3 hrs)Chemistry of selected nonmetal compounds. Prerequisite: CH 601. 621 Methods of Chemical Analysis (3 hrs)Literature, seminar course. Theory and methodology of various techniques of chemical analysis. Prerequisite: Instrumental analysis. 631 Synthetic Organic Chemistry (3 hrs)Survey of certain reactions that enjoy widespread application to the synthesis of organic compounds. Prerequisites: Undergraduate organic chemistry or approval of instructor. 632 Physical Organic Chemistry (3 hrs)Reactive intermediates, structure-activity relationships, reaction mechanisms and techniques used to determine them. Prerequisite: Undergraduate organic chemistry or approval of instructor. 633 Organic Structure Determination (3 hrs)Structure determination of organic molecules using spectroscopic methods, especially NMR, IR, and MS. Emphasis is placed on the theory and interpretation of a wide variety of NMR methods useful in organic chemistry research, including onedimensional and two-dimensional methods. Prerequisite: Undergraduate organic chemistry and instrumental analysis, or approval of instructor. 640 Advanced Chemical Thermodynamics (3 hrs)First, second, and third laws of thermodynamics and applications. Brief introduction to statistical thermodynamics. Prerequisite: Undergraduate physical chemistry or approval of instructor. 641 Statistical Thermodynamics (3 hrs)Principles leading to the development of Maxwell-Boltzmann, Bose-Einstein, and Fermi-Dirac statistics. Thermodynamic properties calculated from partition functions. Prerequisite: Undergraduate physical chemistry. 642 Advanced Chemical Dynamics (3 hrs)Velocity of chemical reactions in homogeneous and heterogeneous systems. Absolute rate theory, collision theory, scattering, and concept of reaction cross sections. Prerequisite: Undergraduate physical chemistry. 643 Quantum Chemistry (3 hrs)Application of quantum theory to the chemical bond. Prerequisite: Undergraduate physical chemistry. 644 Chemical Electrodynamics (3 hrs)Electrodynamics problems encountered in chemistry. Maxwell's equations, electrostatics. Onsager and Debye theory of dielectrics, molecular dipole moments, Beer's law, Landolt's rule, light scattering from macromolecules, quantum theory of radiation, magnetic susceptibility, introduction to NMR and ESR. Prerequisites: Undergraduate physical chemistry and differential equations. 645 Polymer Physical Chemistry (3 hrs)Introduction to structure, properties and processing of polymers. Structural types, structure-property relationships, thermodynamics and kinetics of polymerization and depolymerization, polymer characterization, thermodynamics of polymer solutions and blends, and mechanical evaluation of polymers. Prerequisites: Undergraduate physical chemistry, CH 540. (Same as MTS 747.) 646 Thermodynamics of Materials (3 hrs)Fundamental thermodynamic review, phase equilibrium, chemical reaction equilibrium, free energy, binary and ternary phase transformations, solution models and selected topics. Prerequisite: Undergraduate physical chemistry. (Same as CHE 646 and MTS 646.) 647 Advanced Biophysical Chemistry I (3 hrs)Advanced biophysical chemistry, including computers for data analysis and simulations, first and second laws of thermodynamics, free energy and equilibrium, calorimetry, protein stability, binding and Interactions, solution thermodynamics, electrolytes, and electrochemistry. An emphasis is placed on the current research literature. Prerequisites: Undergraduate physical chemistry and differential equations, or approval of instructor. Students who have completed CH 347 cannot earn credit for CH 647. 648 Advanced Biophysical Chemistry II (3 hrs)Advanced biophysical chemistry, including biochemical reaction kinetics, enzyme catalysis, quantum mechanics, statistical thermodynamics, spectroscopy, including UV-VIS, fluorescence, circular dichroism, NMR, and Structure determinations. An emphasis is placed on the current research literature. Prerequisite: CH 647. Students who have completed CH 348 cannot earn credit for CH 648. 650 Principles of Liquid & Solid Interfaces (3 hrs)Applies basic principles in thermodynamics and kinetics to characterize surfaces and surface phenomena. Fundamental properties of gas-liquid, liquid-liquid, solid-liquid and solid-gas interfaces and phenomena occurring at these interfaces. Prerequisite: Undergraduate physical chemistry. (Same as MTS 650 and CHE 650.) 661 Biological Macromolecules (3 hrs)Detailed analysis of structures of proteins, nucleic acids, and complex polysaccharides. Prerequisite: CH 562. 699 Master's Thesis (3 or 6 hrs)Required each semester a student is enrolled and receiving direction on a master's thesis. Minimum of two terms required. (A maximum of six hours may be applied towards the degree). 700 Current Topics in Chemistry (3 hrs)Advanced laboratory research in one of the departmental research groups. The student works on an independent or group research project. Completion of the course requires a written and an oral report. Prerequisite: approval of the instructor. 705 Selected Topics in Inorganic Chemistry (3 hrs)Prerequisite: CH 600 and approval of instructor. 721 Selected Topics in Analytical Chemistry (3 hrs)Prerequisite: CH 621 and approval of instructor. 735 Selected Topics in Organic Chemistry (3 hrs)Prerequisite: CH 632 and approval of instructor. 745 Selected Topics in Physical Chemistry (3 hrs)Prerequisite: CH 643 and approval of instructor. 746 Solid State Chemistry (3 hrs)Chemical properties of solids. Includes phase equilibria, chemical bonding in ionic and covalent crystals, thermodynamics of atomic defects, ionic conductivity in solids, corrosion, and introduction to surfaces and adsorption. Prerequisites: Undergraduate physical chemistry and differential equations. 765 Selected Topics in Biochemistry (3 hrs)Prerequisites: CH 661 and approval of instructor. 780 Chemistry Seminar (1 hr)Required during each semester of residence. Graduate Courses in Biotechnology Science & Engineering Core/Required Courses CHE 560 Introduction to Bioprocess Engineering (3 hrs)Application of engineering principles to the analysis of and development and design of processes using biological catalysts including enzymes, plant and animal cells and genetically engineered cells. Other topics will include fermentation and biological mass transport processes. Prerequisites: Undergraduate biochemistry. CHE 561 Bioseparations, Recombinant Techniques & Protein Engineering (3 hrs)General characteristics of separation processes used in the biotechnology industry including removal of insolubles, isolation and purification of thermally sensitive products and preparation of products for final use by the customer. Application of unit operation principles for biological separations, recombinant DNA techniques, protein engineering. Prerequisite: CHE 560. CH 561/BYS 547 Biochemistry I (3 hrs)Structural chemistry and function of biomolecules, mechanisms of biochemical reactions, enzyme kinetics, and energy transfer. Prerequisites: Undergraduate organic chemistry and biochemistry. CH 562/BYS 548 Biochemistry II (3 hrs)Biosynthesis of macromolecular precursors, storage, transmission and expression of genetic information, and molecular physiology. Prerequisite: CH 561 or BYS 547. BYS 519 Gene Structure and Function (3 hrs)Advanced studies of macromolecular structure and biological function of proteins and nucleic acids involved in the passage of genetic information and cellular response. Structural significance of viruses and molecular evolution are also included. Prerequisites: Undergraduate genetics, cell biology and biochemistry. BYS 543 Molecular Biology of the Cell (3 hrs)Cellular structure and function including mitosis, meiosis, cell cycle, and cell signaling. Discussion of biological techniques such as tissue culture, hybridoma, and monoclonal antibody production, gene cloning and recombinant DNA, radiotracer methodology, and specialized microscopy. Prerequisites: Undergraduate cell biology. Undergraduate biochemistry is recommended. BSE 601 Current Topics in Biotechnology (3 hrs)Survey of current Biotechnology literature. Students will be required to critically evaluate the assigned literature, develop detailed written summaries and present their critical evaluations to the class and the instructor. Concurrent prerequisites: CHE 560, CH 561/BYS 547. BSE 702 Laboratory Rotations in Biotechnology (3 hrs)Acquire a broad background in biotechnology science and engineering through two 6-week rotations in an active research program under the director of faculty mentors. Students will pursue an independent research project and a detailed written report will be required at the end of each of the two 6-week rotations. Prerequisites: BSE 601. BSE 799 Doctoral Dissertation (3, 6, 9 hrs)Required each semester student is enrolled and receiving direction on a doctoral dissertation. Specialized/Track Courses BSE 620 Introduction to Bioinformatics: Fundamentals and Methodology (3 hrs)Students will learn how computational and mathematical techniques are being used to understand DNA and protein sequences, how the information from the genome is being used to understand phenomena at a macro-level. Prerequisites: Graduate student admitted to the Ph.D. program in Biotechnology Science and Engineering. Graduate students in other programs may seek permission from the Director of the Biotechnology Science and Engineering Program to take this class. Corequisite: BSE 621. BSE 621 Introduction to Bioinformatics: Computer Laboratory for Applications (1 hr)Students will use a variety of computational tools and software for data mining, sequence alignment, phylogenetic analysis, clustering, quantitative metabolic pathways analysis and other topics covered in BSE 620. Prerequisites: Graduate student admitted to the Ph.D. program in Biotechnology Science and Engineering. Graduate students in other programs may seek permission from the Director of the Biotechnology Science and Engineering Program to take this class. Corequisite: BSE 620. Programs BSE 703 Biotechnology Research (3 hrs)Advanced research in a specific targeted topic under the direct supervision of a faculty member in collaboration with scientists and researchers at a biotechnology company or business or a research laboratory that has specific relevance to the biotechnology science and engineering program. Completion of this course will require a written report and an oral presentation to the faculty and students in the biotechnology program. Prerequisites: BSE 601, BSE 702, BYS 543, BYS 519, CHE 561. Exceptions to these prerequisites can be made by appeal to the Coordinator of the Biotechnology Program. BYS 556 Advanced Molecular Techniques (3 hrs)Laboratory techniques in molecular biology, including methods of recombinant DNA technology for identification, cloning, and characterization of genes. Prerequisites: Undergraduate cell biology and genetics and BYS 519 (may be taken concurrently) or approval of instructor. One 2-hour and one 5-hour lab per week. Lab Fee: $250. BYS 691 Special Topics in Tissue Culture (3 hrs)Lecture and laboratory instruction in the preparation and maintenance of eucaryotic cell primary cultures and cell lines. Teaches students the basic techniques for tissue culture - aseptic technique, media preparation, equipment needs. Introduces them to several procedures used for isolating primary cultures from tissue and for culturing cell lines. Covers culture characterization and contamination issues. Prerequisites BYS 543 or BYS 547/CH 561. BYS 691 Special Topics in Growth Factors and Oncogenes (3 hrs)Discussion of the cell cycle, the nature of growth factors and their relationship to oncogenes and cancer. This course is designed to provide an in-depth understanding of the regulation of the cell cycle and cell function by growth factors and the relationship between growth factors, oncogenes and cancer. Textbooks will provide the basic framework for the course, but a large part of the material will come from the latest published research articles. Prerequisites BYS 543 and BYS 547/CH 561. CH 565 Molecular Biochemistry Laboratory (3 hrs)Practical experience in isolation, characterization and manipulation of biomolecules. Lab Fee: $60. Prerequisite: CH 562. CH 661 Biological Macromolecules (3 hrs)Detailed analysis of structures of proteins, nucleic acids, and complex polysaccharides. Prerequisite: CH 562. CH 765 Selected Topics in Biochemistry (3 hrs)Prerequisites: CH 661 and approval of instructor CHE 559 Special Topics in Polymeric Drug Delivery Systems (3 hrs)Discussion of biocompatible polymers and their application in drug delivery systems. Polymers of natural and synthetic origin will be studied, special emphasis will be placed upon the synthesis of biocompatible polymers. The formation of polymeric micelles, hydrogels and liposomes will be studied. The process of extravasation as uptake mechanism for polymeric delivery systems will be discussed. Reading material will be based on the latest publications in the field. Prerequisites: CH 540. CHE 650 Principles of Liquid and Solid Interfaces (3 hrs)Basic principles in thermodynamics and kinetics applied to characterize surfaces and surface phenomena. Fundamental properties of gas-liquid, liquid-liquid, solid-liquid, an solid-gas interfaces and phenomena occurring at these interfaces. Prerequisite: CH 341. CHE 659 Special Topics: Advanced Enzymology (credit to be arranged) CHE 747 Advanced Topics in Bioengineering (3 hrs)Engineering aspects of microbial processes and processing of biological materials. Integrating knowledge of governing biological properties and principles with chemical engineering methodology. Emphasis on current literature in the areas of purification and separation technology, bioprocess development and biomaterials. Prerequisite: B.S. in chemical engineering or permission of instructor.