UAH

William N. Setzer

setzer w

Chair, Department of Chemistry
Professor, Organic Chemistry

Adjunct Professor, Biological Sciences

Office: MSB 115
Phone: 256.824.6519
Fax: 256.824.6349
Email: wsetzer@chemistry.uah.edu

Résumé

Research Interests

My current research interests are concerned with secondary metabolites of higher plants; biomedicinal aspects of biologically active phytochemicals and chemical ecology.

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Selected Publications

“Lignin-derived oak phenolics:  A theoretical examination of additional potential health benefits of red wine.”  Setzer, W.N.  Journal of Molecular Modeling, 2011, 17, 1841-1845.

“Chemical compositions of the leaf essential oils of Aralia spinosa from three habitats in northern Alabama.”  Davé, P.C.; Vogler, B.; Setzer, W.N.  American Journal of Plant Sciences, 2011, 2, 507-510.

“Vitexin inhibits polyubiquitin synthesis by the ubiquitin-conjugating enzyme E2-25K.”  Helms, K.M.; Wilson, R.C.; Ogungbe, I.V.; Setzer, W.N.; Twigg, P.D.  Natural Product Communications, 2011, 6, 1411-1416.

“Peptidyl-tRNA hydrolase screening combined with molecular docking reveals the antibiotic potential of Syzygium johnsonii bark extract.”  Harris, S.M.; McFeeters, H.; Ogungbe, I.V.; Cruz-Vera, L.R.; Setzer, W.N.; Jackes, B.R.; McFeeters, R.L.  Natural Product Communications, 2011, 6, 1421-1424.

“Drugs from the cloudforest:  The search for new medicines from Monteverde, Costa Rica.”  Setzer, W.N.  Natural Product Communications, 2011, 6, 1549-1558.

“Allelopathic potential of Sassafras albidum and Pinus taeda essential oils.”  Kennedy, J.E.; Davé, P.C.; Harbin, L.N.; Setzer, W.N.  Allelopathy Journal, 2011, 27, 111-122.
 
“The essential oil of Artemisia scoparia from Tajikistan is dominated by phenyldiacetylenes.”  Sharopov, F.S.; Setzer, W.N.  Natural Product Communications, 2011, 6, 119-122.
 
“Comparative chemical, cytotoxicity, and antileishmanial properties of essential oils from Chenopodium ambrosioides.”  Monzote, L.; Nance, M.R.; García, M.; Scull, R.; Setzer, W.N.  Natural Product Communications, 2011, 6, 281-286.
 
“Chemical diversity of Ziziphora clinopodioides Lam.:  Composition of the essential oil of Z. clinopodioides from Tajikistan.” Sharopov, F.S.; Setzer, W.N.  Natural Product Communications, 2011, 6, 695-698.
 
“A new chemical form of essential oil of Hyssopus officinalis L. (Lamiaceae) from Nigeria.”  Ogunwande, I.A.; Flamini, G.; Alese, O.O.; Cioni, P.L.; Ogundajo, A.L.; Setzer, W.N.  International Journal of Biological and Chemical Sciences, 2011, 5, 46-55.
 
“Volatile components of aroma hops (Humulus lupulus L.) commonly used in beer brewing.”  Nance, M.R.; Setzer, W.N.  Journal of Brewing and Distilling, 2011, 2, 16-22.
 
“Thujone-rich essential oils of Artemisia rutifolia growing wild in Tajikistan.”  Sharopov, F.S.; Setzer, W.N.  Journal of Essential Oil-Bearing Plants, 2011, 14, 136-139.

Phytomedicinal agents for treatment of schistosomiasis.  Divya Haridas and William N.  Setzer.  Recent Progress in Medicinal Plants, Drug Plants III, 2010, 29, 79-91 (Chapter 7).

A DFT analysis of thermal decomposition reactions important to natural products.  William N. Setzer.  Natural Product Communications, 2010, 5, 993-998.

Phytochemical investigation of Verbesina turbacensis Kunth:  Trypanosome cysteine protease inhibition by (–)-bornyl esters.”  Ifedayo V. Ogungbe, Rebecca A. Crouch, William A. Haber, and William N. Setzer.  Natural Product Communications, 2010, 5, 1161-1166.

Antennal electrophysiological responses of the giant swallowtail butterfly, Papilio cresphontes, to the essential oils of Zanthoxylum clava-herculis and related plants. Henry Fadamir, Li Chen, Clement Akotsen-Mensah and William N. Setzer. Chemoecology, 2010, 20, 25-33. (abstract)

The chemical composition and antimirobial activity of the leaf oil of Cupressus lusitanica from Monteverde, Costa Rica. Sara L. Hassanzadeh, Jessika A Tuten, Bernhard Vogler, and William Setzer. Pharmacognosy Research, 2010, 2, 19-21. (abstract)

Cembrene diterpenoids: Conformational studies and molecular docking to tubulin. Heather E. Villanueva and William N. Setzer. Records of Natural Products. 2010. 4, 115-123. (abstract

Cancer-relevant biochemical targets of cytotoxic Lonchocarpus flavonoids: A molecular docking analysis.  Caitlin E. Cassidy and William N. Setzer, Journal of Molecular Modeling, 2010, 16(2), 311-326.

Essential oils and anxiolytic aromatherapy.  William N. Setzer.  Natural Product Communications, 2009, 4, 1305-1316. 

Quinoline alkaloids as intercalative topoisomerase inhibitors.  Kendall G. Byler, Chen Wang, and William N. Setzer.  Journal of Molecular Modeling, 2009, 15, 1417-1426. (abstract).

Conformational analysis of thioether musks using density functional theory.  William N. Setzer.  International Journal of Molecular Sciences (special issue on “Applications of Density Functional Theory”), 2009, 10, 3488-3501. (abstract)

Chemical compositions and cytotoxic activities of leaf essential oils of four Lauraceae tree species from Monteverde, Costa Rica.  Maria C. Palazzo, Brittany R. Agius, Brenda S. Wright, William A. Haber, Debra M. Moriarity, and William N. Setzer.  Records of Natural Products, 2009, 3, 32-37 (abstract).

A theoretical investigation of cytotoxic activity of celastroid triterpenoids.  William N. Setzer.  Journal of Molecular Modeling, 2009, 15, 197-201 (abstract).

Essential oil compositions of three Lantana species from Monteverde, Costa Rica.  Ashley B. Walden, William A. Haber, and William N. Setzer.  Natural Product Communications, 2009, 4, 105-108.

Essential oil compositions and cytotoxic activities of Dendropanax capillarisOreopanax nubigenus, andSchefflera rodrigueziana from Monteverde, Costa Rica.  Justin D. Richmond, Brittany R. Agius, Brenda S. Wright, William A. Haber, Debra M. Moriarity, and William N. Setzer.  Natural Product Communications, 2009,4, 271-274.

Chemical composition of the leaf essential oil of Casimiroa edulis from Monteverde, Costa Rica.  Sarah L. Miller, William A. Haber, and William N. Setzer.  Natural Product Communications, 2009, 4, 425-426.

Composition of the floral essential oil of Brugmansia suaveolens.  Samuel J. Anthony, Willow Zuchowski, and William N. Setzer.  Records of Natural Products, 2009, 3, 76-81 (abstract).

A theoretical investigation into the formation of sesquiterpene episulfides.  William N. Setzer.  Journal of Sulfur Chemistry, 2009, 30, 119-127.

Monoterpene hydrocarbons may serve as antipredation defensive compounds in Boisea trivittata, the boxelder bug.  Maria C. Palazzo and William N. Setzer.  Natural Product Communications, 2009, 4, 457-459.

Comparative molecular docking of antitrypanosomal natural products into multiple Trypanosoma brucei drug targets.  Ifedayo V. Ogungbe and William N. Setzer, Molecules 2009, 14, 1513-1536 (abstract).