Dr. Kyung-Ho Roh

 

 

Dr. Kyung-Ho Roh

Assistant Professor, Chemical and Materials Engineering

Biography

Kyung-Ho Roh joined the Chemical and Materials Engineering Department as Assistant Professor in Fall 2016. Dr. Roh received his Ph.D. degree in Macromolecular Science and Engineering from the University of Michigan in 2008, and his M.S. and B.S. degrees in Fiber and Polymer Science and Engineering from Seoul National University, South Korea.

Upon completion of his Ph.D., he studied for 5 years in the School of Medicine at Stanford University for his postdoctoral study on T cell immunology. Immediately before joining UAH, Dr. Roh worked as a Research Scientist in the Biomedical Engineering Department at the Georgia Institute of Technology and Emory University, and he also served as a Program Manager for the National Cell Manufacturing Consortium. 

With his interdisciplinary research experiences, his research interests are at the intersection of biomaterials and immunology. In particular, Dr. Roh is mainly interested in developing strategies for i) artificial microenvironments for effective regeneration and induction of adaptive immunity using therapeutically relevant sources such as naïve/stem/progenitor cells, ii) controlled immuno-activation or modulation in selective immune cell populations, and iii) engineering receptor-ligand interactions within the immunological synapse in healthy and diseased states. The common end goal of his research topics is the development of biomaterials-based translational cellular and molecular immunotherapies for cancers, infections, and autoimmune diseases.

Personal Website

Education

  • Ph.D., Macromolecular Science and Engineering, University of Michigan, 2008

    M.S., Fiber and Polymer Science and Engineering, Seoul National University, 2000

  • B.S., Fiber and Polymer Science and Engineering, Seoul National University, 1998


Publications

  • K. H. Roh and K. Roy, "Engineering approaches for regeneration of T lymphopoiesis," Biomater Res, vol. 20, p. 20, 2016.
  • K. H. Roh, R. M. Nerem, and K. Roy, "Biomanufacturing of Therapeutic Cells: State of the Art, Current Challenges, and Future Perspectives," Annu Rev Chem Biomol Eng, vol. 7, pp. 455-78, Jun 7 2016.
  • K. H. Roh, B. F. Lillemeier, F. Wang, and M. M. Davis, "The coreceptor CD4 is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase p56lck," Proc Natl Acad Sci U S A, vol. 112, pp. E1604-13, Mar 31 2015.
    • K. H. Roh and K. Roy, "Engineering approaches for regeneration of T lymphopoiesis," Biomater Res, vol. 20, p. 20, 2016.
    • K. H. Roh, R. M. Nerem, and K. Roy, "Biomanufacturing of Therapeutic Cells: State of the Art, Current Challenges, and Future Perspectives," Annu Rev Chem Biomol Eng, vol. 7, pp. 455-78, Jun 7 2016.
    • K. H. Roh, B. F. Lillemeier, F. Wang, and M. M. Davis, "The coreceptor CD4 is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase p56lck," Proc Natl Acad Sci U S A, vol. 112, pp. E1604-13, Mar 31 2015.
    • F. Bertrand, S. Muller, K. H. Roh, C. Laurent, L. Dupre, and S. Valitutti, "An initial and rapid step of lytic granule secretion precedes microtubule organizing center polarization at the cytotoxic T lymphocyte/target cell synapse," Proc Natl Acad Sci U S A, vol. 110, pp. 6073-8, Apr 9 2013.
    • S. Hwang, K. H. Roh, D. W. Lim, G. Wang, C. Uher, and J. Lahann, "Anisotropic hybrid particles based on electrohydrodynamic co-jetting of nanoparticle suspensions," Phys Chem Chem Phys, vol. 12, pp. 11894-9, Oct 14 2010.
    • M. Yoshida*, K. H. Roh*, S. Mandal, S. Bhaskar, D. Lim, H. Nandivada, et al., "Structurally Controlled Bio-hybrid Materials Based on Unidirectional Association of Anisotropic Microparticles with Human Endothelial Cells," Adv Mater, vol. 21, pp. 4920-5, Dec 28 2009. *Equal contribution
    • A. H. Talasaz, A. A. Powell, D. E. Huber, J. G. Berbee, K. H. Roh, W. Yu, et al., "Isolating highly enriched populations of circulating epithelial cells and other rare cells from blood using a magnetic sweeper device," Proc Natl Acad Sci U S A, vol. 106, pp. 3970-5, Mar 10 2009.
    • M. Yoshida, K. H. Roh, and J. Lahann, "Short-term biocompatibility of biphasic nanocolloids with potential use as anisotropic imaging probes," Biomaterials, vol. 28, pp. 2446-56, May 2007.
    • K. H. Roh, M. Yoshida, and J. Lahann, "Water-stable biphasic nanocolloids with potential use as anisotropic imaging probes," Langmuir, vol. 23, pp. 5683-8, May 8 2007.
    • K. H. Roh, D. C. Martin, and J. Lahann, "Triphasic nanocolloids," J Am Chem Soc, vol. 128, pp. 6796-7, May 31 2006.
    • K. H. Roh, D. C. Martin, and J. Lahann, "Biphasic Janus particles with nanoscale anisotropy," Nat Mater, vol. 4, pp. 759-63, Oct 2005.
    • I. H. Lee, Y. T. Park, K. Roh, H. Chung, I. C. Kwon, and S. Y. Jeong, "Stable paclitaxel formulations in oily contrast medium," J Control Release, vol. 102, pp. 415-25, Feb 2 2005.
    • B. C. Cho, T. G. Kim, J. D. Yang, H. Y. Chung, J. W. Park, I. C. Kwon, et al., "Effect of calcium sulfate-chitosan composite: pellet on bone formation in bone defect," J Craniofac Surg, vol. 16, pp. 213-24; discussion 225-7, Mar 2005.
    • B. C. Cho, H. Y. Chung, D. G. Lee, J. D. Yang, J. W. Park, K. H. Roh, et al., "The effect of chitosan bead encapsulating calcium sulfate as an injectable bone substitute on consolidation in the mandibular distraction osteogenesis of a dog model," J Oral Maxillofac Surg, vol. 63, pp. 1753-64, Dec 2005.
    • K. H. Roh, S. Y. Lee, I. C. Kwon, S. Y. Jeong, and H. Chung, "Honeycomb mesh structure of poly(L-lactic acid) prepared by lipid cubic mesophase induced phase separation," Biophysical Journal, vol. 86, pp. 163a-163a, Jan 2004.
    • K. H. Roh, S. Y. Lee, I. C. Kwon, S. Y. Jeong, and H. Chung, "Hydrophilic polymers stabilize eutectic mixture of monoglyceride and triglyceride," Biophysical Journal, vol. 86, pp. 163a-163a, Jan 2004.
    • B. C. Cho, J. Y. Kim, J. H. Lee, H. Y. Chung, J. W. Park, K. H. Roh, et al., "The bone regenerative effect of chitosan microsphere-encapsulated growth hormone on bony consolidation in mandibular distraction osteogenesis in a dog model," J Craniofac Surg, vol. 15, pp. 299-311; discussion 312-3, Mar 2004.