Setzer, W.N., T.J. Green, K.W. Whitaker, D.M. Moriarity, C.A. Yancey, R.O. Lawton, and R.B. Bates. 1995. A cytotoxic diacetylene from Dendropanax arboreus. Planta Medica 61: 470-471.
The crude ethanol extract from the leaves of Dendropanax arboreus (Araliaceae) from Monteverde, Costa Rica, exhibits cytotoxic activity against Hep-G2, A-431, H-4IIE, and L-1210 tumor cell lines, but is not toxic against normal hepatocytes. The active component has been isolated by activity-directed separation and identified by 1H- and 13C-NMR spectroscopy as the acetylenic compound cis-1,9-16-heptadecatriene-4,6-diyne-3,8-diol.
