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Dr.
Joseph D. Ng
Associate Professor and
Coordinator of Biotech Ph.D Program
Department of Biological Sciences
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Visit our
lab
www/uah.edu/nglab
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Structural biology, Proteomics, X-ray
crystallography
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Our primary goal is to investigate how the diversity and abundance
of life are reflected upon the structure and function of
proteins derived from extremophilic
organisms.
Focus
Methods and tool development for high throughput protein
crystallization
Structural and biochemical studies of extremophilic
macromolecules
Proteomic investigation of hyperthermophilic
microorganisms
Techniques applied in research
Molecular cloning and recombinant expression
Biochemical characterization
Protein crystallization
X-ray crystallography
Opportunities for
undergraduate, graduate and postdoctoral research
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Selected Publications
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- Ng,
J.D., Stevens, R.C. and Kuhn P. (2007). Protein
crystallization in restricted geometry: advancing old
ideas for modern times in structural proteomics. Methods in Molecular Biology (In press)
- Pikuta,
E., Marsic, D., Itoh, T., Bej, A.K., Tang, J., Whitman, W.,
Ng, J.D., Garriott, O.K. and Hoover, R.B. (2007). Thermococcus thioreducens sp. nov., a
novel hyperthermophilic, obligately sulfur-reducing archaeon from a deep-sea
hydrothermal vent. J Syst Evol Microbiol.
(In press)
- Baird, J.K., Caraballo, K.
and Ng, J.D. (2007).
Kinetics of protein crystallization. Book Chapter
in Focus on Crystal
Growth Research (Ed: G.V. Karas) pp
173-195. (In press).
- Ng, J.D. and Garcia-Ruiz,
J.M. (2006). Counter-diffusion capillary
crystallization for structural genomics. Trends in Drug
Discovery 3:36.
- Garcia-Ruiz,
J.M. and Ng, J.D.
(2006). Counter-diffusion capillary crystallization for high
throughput applications. In Protein crystallization strategies for
structural genomics (N. E. Chayen, ed)
International University Line Chapter 5.
- Caraballo, K.G., Baird, J.K. and Ng,
J.D. (2006). Kinetics
of Supersaturation Decay in the Crystallization of
Canavalin. Crystal
Growth and Design. 6:874-880. .
- Liu, Z. J.; Tempel, W.; Ng, J. D.; Lin, D.; Shah, A. K.; Chen, L.;
Horanyi, P. S.; Habel, J.; Kataeva, I.; Xu, H.; Yang, H.;
Chang, J. C.; Huang, L.; Chang, S.; Zhou, W.; Lee, D.; Praissman, J.; Zhang, H.; Newton, M.
G.; Rose, J. P.; Richardson, J. S.; Richardson, D. C.;
Wang, B.-C.(2005).
The High Throughput Protein to Structure Pipeline
at SECSG. Acta Crystallogr D Biol Crystallogr
61:679-84.
- Ng, J.D., Gavira, J.A. and Garcia-Ruiz
MA. (2003). Protein
crystallization by capillary counter-diffusion for
applied crystallographic structure determination. Journal of Structural
Biology 142:218-231.
- Gavira,
J.A., Lopéz-Jaramillo, J.,
Toh, D., Garcia-Ruiz, J.M. and Ng, J.D.
(2002). Ab
initio crystallographic structure determination of
insulin form protein to electron density without crystal
handling. Acta Crystallogr
D58 :1085-1254
View more
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