The focal point for my various research activities centers on the biologic actions of the steroid hormones, particularly in regard to the development and function of the reproductive system. I use the laboratory rodent as the biologic model system and employ a multifaceted approach to discovery, including physiologic (whole organism), biochemical and cellular techniques. Past research endeavors have investigated the role of steroid hormones in the development of the female reproductive system and the neural patterning of reproductive regulatory centers and how steroid hormone antagonists affect uterine growth, metabolism and physiologic function. The role of estrogen signaling in regulating growth factors such as EGF during cyclic uterine growth has also been a focus of study. More recently, studies have been undertaken to look at the role that various chemicals that act as estrogen mimics (endocrine disrupters) might have upon male and female reproductive system development and fertility. I also have conducted research on the efficacy and potential therapeutic value of some over-the-counter herbal supplements for the treatment of benign prostate hypertrophy (BPH). Finally, the effect of mega doses of vitamin C ingestion on adrenal gland function in response to stress has produced interesting and promising results regarding a possible endocrine pathway by which this vitamin may produce physiologic benefit.
Selected Publications
Germain, B. J., Campbell, P. S., and Anderson, J. N. Role of the serum estrogen binding protein in the control of tissue estradiol levels during postnatal development of the female rat. Endocrinology 103:1401, 1978.
Campbell, P. S. Impaired prepubertal uterine responsivity after neonatal exposure to steroid hormone esters. J. Exp. Zool. 214:345, 1980.
Campbell, P. S. An early effect of testosterone propionate upon hypothalamic function in the neonatal rat. Experientia 38:108, 1983.
Campbell, P. S. and Satterfield, P. M. Effect of neonatal exposure to the antioestrogens nafoxidine and CI‑628 upon the development of the uterus in the prepubertal rat.J.Reprod. Fert. 83:225, 1988.
Campbell, P. S. and Swanson, K. A. Preferential nuclear binding of estrogen in the formalin fixed rat uterus. J. Steroid Biochem. 36:703, 1990.
Campbell, P. S., Ben‑Aryeh, H. and Swanson, K. A. Differential distribution of an estrogen receptor in the submandibular and parotid salivary glands of female rats. Endocrine Res. 16:333, 1990.
Kirkpatrick, S. W., Campbell, P. S., Wharry, R. E., and Robinson, S. L. Salivary
testosterone in Children with and without learning disabilities. Physiol. Behav. 53:583, 1993.
Campbell, P. S., Moriarity, D. M., and Mousel, K. A. Epidermal growth factor (EGF) concenteration In the submandibular gland (SG) is affected by both estrogen and androgen.
Endocrine Society 77th Annual Meeting Program and Abstracts, P1-431, June 14-17, 1995.
Campbell, P. S. and Harris, M. W. The effects of a very low dose of estradiol on the maturation of the male rat reproductive system and its relevance to environmental estrogen pollution. Biol. Reprod. 60 (Suppl. 1):139, 1999.
Green, K. A. and Campbell, P. S. Saw Palmetto: An effective form of phytotherapy for the treatment of benign prostate hyperplasia (BPH)? Biol. Reprod. 62 (Suppl. 1): 187, 2000.
